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Article

Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing.

Gene - 5 Feb 2021

Wang Xing, Hayes James E, Xu Xing, Gao Xiaoni, Mehta Dipti, Lilja Hans G, Klein Robert J

Abstract excerpt

GWAS have identified numerous SNPs associated with prostate cancer risk. One such SNP is rs10993994. It is located in the β-microseminoprotein (MSMB) promoter region, mediates MSMB prostate secretion levels, and is linked to mRNA expression changes in both MSMB and the adjacent gene NCOA4. In addition, our previous work showed a second SNP, rs7098889, is in positive linkage disequilibrium with rs10993994 and...

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Identifiers

PMID: 33122083
DOI: 10.1016/j.gene.2020.145265
PMCID: PMC7796996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing.PMID 33122083Read ↗

Validation of prostate cancer risk variants by CRISPR/Cas9 mediated genome editingSemantic proximity Read ↗

Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility.Semantic proximity Read ↗

Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancer.Semantic proximity Read ↗

The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine.Semantic proximity Read ↗

Investigation of the relationship between prostate cancer and MSMB and NCOA4 genetic variants and protein expression.Semantic proximity Read ↗

Prostate cancer risk SNP rs10993994 is a trans-eQTL for SNHG11 mediated through MSMB.Semantic proximity Read ↗

Analysis of the 10q11 cancer risk locus implicates MSMB and NCOA4 in human prostate tumorigenesis.Semantic proximity Read ↗

A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations.Semantic proximity Read ↗

Fine mapping association study and functional analysis implicate a SNP in MSMB at 10q11 as a causal variant for prostate cancer risk.Semantic proximity Read ↗

Mutation analysis of the MSMB gene in familial prostate cancer.Semantic proximity Read ↗

Microseminoprotein-Beta Expression in Different Stages of Prostate Cancer.Semantic proximity Read ↗

Levels of beta-microseminoprotein in blood and risk of prostate cancer in multiple populations.Semantic proximity Read ↗

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