Article
NOX1 Regulates Collective and Planktonic Cell Migration: Insights From Patients With Pediatric-Onset IBD and NOX1 Deficiency.
Inflammatory bowel diseases - 17 Jul 2020
Khoshnevisan Razieh, Anderson Michael, Babcock Stephen, Anderson Sierra, Illig David, Marquardt Benjamin, Sherkat Roya, Schröder Katrin, Moll Franziska, Hollizeck Sebastian, Rohlfs Meino, Walz Christoph, Adibi Peyman, Rezaei Abbas, Andalib Alireza, Koletzko Sibylle, Muise Aleixo M, Snapper Scott B, Klein Christoph, Thiagarajah Jay R, Kotlarz Daniel
Abstract excerpt
BACKGROUND: Genetic defects of pediatric-onset inflammatory bowel disease (IBD) provide critical insights into molecular factors controlling intestinal homeostasis. NOX1 has been recently recognized as a major source of reactive oxygen species (ROS) in human colonic epithelial cells. Here we assessed the functional consequences of human NOX1 deficiency with respect to wound healing and epithelial migration by...
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