Back to search

Article

Olfactomedin-4 <sup>+</sup> neutrophils exacerbate intestinal epithelial damage and worsen host survival after <i>Clostridioides difficile</i> infection

2023-08-22

Abstract excerpt

Neutrophils are key first responders to Clostridioides difficile infection (CDI). Excessive tissue and blood neutrophils are associated with worse histopathology and adverse outcomes, however their functional role during CDI remains poorly defined. Utilizing intestinal epithelial cell (IEC)-neutrophil co-cultures and a pre-clinical animal model of CDI, we show that neutrophils exacerbate C. difficile -induced IE...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ef2bba85-6c5a-54ae-a884-98b78cfe984c
DOI
10.1101/2023.08.21.553751
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Olfactomedin-4 <sup>+</sup> neutrophils exacerbate intestinal epithelial damage and worsen host survival after <i>Clostridioides difficile</i> infectionDOI 10.1101/2023.08.21.553751
Phenotypic profiling of neutrophils in acute Clostridioides difficile infection identifies a TNF-induced activation signature associated with epithelial damage.Semantic proximity
A New Hypothesis for <em>Clostridioides difficile</em> Infection Vulnerability: Epithelial Damage and Inflammatory Repair May Prime the Host for InfectionSemantic proximity
Pro-inflammatory Pathways Contribute to Pathogenesis of <i>Clostridioides difficile</i> Infection in a Murine Model - A Spatial Transcriptomics StudySemantic proximity
Colonic epithelial regeneration shapes susceptibility to <i>Clostridioides difficile</i> infectionSemantic proximity
Neutrophils prime unique transcriptional responses in intestinal organoids during infection with nontyphoidal <i>Salmonella enterica</i> serovarsSemantic proximity
Gene Expression Dysregulation in Whole Blood of Patients with Clostridioides difficile InfectionSemantic proximity
IFNAR1⁺ Neutrophils Orchestrate Chronic Inflammatory Damage Through Mitochondrial RemodelingSemantic proximity
Neutrophil Plasticity and De Novo DUOX2 Expression in Inflammatory Bowel Disease Pathogenesis: A Review of Single-Cell Transcriptomic Advances and Therapeutic StrategiesSemantic proximity
Neutrophil Plasticity and De Novo DUOX2 Expression in Inflammatory Bowel Disease Pathogenesis: A Review of Single-Cell Transcriptomic Advances and Therapeutic StrategiesSemantic proximity
Neutrophil-T cell crosstalk in inflammatory bowel disease.Semantic proximity
Epithelia mediate inflammation with myeloid cells in Crohn’s disease patients under treatmentSemantic proximity
Active eosinophils regulate host defence and immune responses in colitisSemantic proximity
Select a neighboring publication to make it the new centre.