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Article

Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras.

International journal of cancer - 1 Jul 2008

Laurent Eunice, McCoy James W, Macina Roberto A, Liu Wenhui, Cheng Guangjie, Robine Sylvie, Papkoff Jackie, Lambeth J David

Abstract excerpt

The NADPH-oxidase 1 (Nox1) is a homolog of gp91phox, the catalytic subunit of the phagocyte superoxide-generating NADPH-oxidase. Nox1 is expressed in normal colon epithelial cells and in colon tumor cell lines, and overexpression in model cells has been implicated in stimulation of mitogenesis and angiogenesis and inhibition of apoptosis. This suggests that aberrant expression of Nox1 could contribute to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18398843
DOI: 10.1002/ijc.23423
PMCID: PMC3774003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras.PMID 18398843Read ↗

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