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Article

Overexpression of a Novel Noxo1 Mutant Increases Ros Production and Noxo1 Relocalisation.

International journal of molecular sciences - 28 Feb 2023

Benssouina Fatima-Zahra, Parat Fabrice, Villard Claude, Leloup Ludovic, Garrouste Françoise, Sabatier Jean-Marc, Ferhat Lotfi, Kovacic Hervé

Abstract excerpt

Noxo1, the organizing element of the Nox1-dependent NADPH oxidase complex responsible for producing reactive oxygen species, has been described to be degraded by the proteasome. We mutated a D-box in Noxo1 to express a protein with limited degradation and capable of maintaining Nox1 activation. Wild-type (wt) and mutated Noxo1 (mut1) proteins were expressed in different cell lines to characterize their phenotype,...

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Identifiers

PMID: 36902094
DOI: 10.3390/ijms24054663
PMCID: PMC10003393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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