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NOX1 and NPY1R mark regional colon stem cell populations that serve as cancer origins in vivo

2 Sept 2025

Abstract excerpt

Current colorectal cancer mouse models either lack colon specificity, limiting progression towards more advanced disease, or preclude evaluation of resident stem cells as cancer origins. Here we report the identification of NOX1 and NPY1R as cell-surface markers enriched in LGR5+ stem cells predominantly within the caecum and exclusively within the middle and distal colorectum, respectively. Selective...

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PMID: 40897804
DOI: 10.1038/s41556-025-01763-1

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