Article

Distinct steady-state properties and TNF responses of epithelial long myosin light chain kinase (MLCK) splice variants

2022-10-14

Abstract excerpt

<h4>ABSTRACT</h4> Intestinal epithelia express two long myosin light chain kinase (MLCK) splice variants, MLCK1 and MLCK2. Unlike MLCK2, MLCK1 is concentrated at the perijunctional actomyosin ring and this localization is enhanced by tumor necrosis factor (TNF) signaling. Here we sought to identify and characterize the domain(s) that direct basal and TNF-induced MLCK1 subcellular localization. Quantitative morpho...

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Literature Corpus work: 21eb2a41-9db9-50cd-ad3e-9af8e0f6c8ad
DOI: 10.1101/2022.10.13.512159

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