NOX5 is Expressed Aberrantly but Not a Critical Pathogenetic Gene in Hirschsprung Disease

Abstract excerpt

<h4>Background: </h4> Hirschsprung disease (HSCR) is a congenital disorder characterized by the absence of intramural ganglion cells in the distal gastrointestinal tract (GI), which results in tonic contraction of the aganglionic gut segment and functional intestinal obstruction. Recent studies have suggested NADPH oxidase 5 (NOX5) as a candidate risk gene for HSCR. In this study, we examined the function of NOX5...

Topics

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• Abnormalities, Multiple
• Congenital gastrointestinal and neural anomalies
• Enteric Nervous System
• Follow-Up Studies
• Hirschsprung Disease
• Incidence
• Infant, Newborn
• Risk Assessment

Identifiers and source

Literature Corpus work

d56c9d57-7378-5b69-8eb4-bb1bf69964e6

DOI

10.21203/rs.3.rs-45296/v1