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Article

Phenotypic profiling of neutrophils in acute Clostridioides difficile infection identifies a TNF-induced activation signature associated with epithelial damage.

Gut microbes - 31 Dec 2026

Huber Alexander, Mathew Ann, Khondokar Faiza, Sharma Divya, Mukherjee Anindita, Khona Dolly K, Gabriel Jucy, Jose Shinsmon, Madan Rajat

Abstract excerpt

Neutrophils are key first responders in the host response to Clostridioides difficile infection (CDI). Although a high number of tissue and blood neutrophils clearly correlates with adverse outcomes in CDI patients, their functional role remains poorly defined. Using murine (CMT-93) and human (Caco-2) intestinal epithelial cell (IEC) lines co-cultured with neutrophils and a pre-clinical mouse model of CDI, we...

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Identifiers

PMID: 42023517
DOI: 10.1080/19490976.2026.2659430
PMCID: PMC13108352

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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