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Article

Beyond genetics: driving cancer with the tumour microenvironment behind the wheel.

Nature reviews. Cancer - 1 Apr 2024

Yuan Shaopeng, Almagro Jorge, Fuchs Elaine

Abstract excerpt

Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is fuelled by studies showing that ageing tissues are often riddled with clones of complex oncogenic backgrounds coexisting in seeming harmony with their normal tissue counterparts. Equally puzzling, however, is how cancer cells harbouring high mutational burden contribute to normal, tumour-free mice when allowed to develop...

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Identifiers

PMID: 38347101
DOI: 10.1038/s41568-023-00660-9
PMCID: PMC11077468

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