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Article

The Long Evolutionary Journey of Cancer from Ancestor to Modern Humans.

Critical reviews in oncogenesis - 1 Jan 2017

Carruba Giuseppe, Trosko James E

Abstract excerpt

In this article, we review various key issues in cancer development and progression that have important implications for both cancer prevention and treatment: (1) evolutionary aspects of cancer appearance; (2) evidence of organ-specific adult stem cells as cancer-initiating cells; (3) the immortality of cancer-initiating cells; (4) cancer cell loss of growth control, contact inhibition, terminal differentiation,...

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Identifiers

PMID: 29604908
DOI: 10.1615/CritRevOncog.2018025227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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