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Article

Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations.

Biochimica et biophysica acta - 1 Jan 2008

Marusyk Andriy, DeGregori James

Abstract excerpt

Age is the single most important prognostic factor in the development of many cancers. The major reason for this age-dependence is thought to be the progressive accumulation of oncogenic mutations and epigenetic changes. Similarly, mutagens are thought to be carcinogenic primarily by engendering...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17980163
DOI: 10.1016/j.bbcan.2007.09.001
PMCID: PMC2234267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17980163-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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