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Article

Environmental Carcinogenesis as a Stochastic Evolutionary Failure of Senescence-Control Systems.

Cells - 8 Jul 2026

Blanco Jose-Ramon, Carnero Amancio

Abstract excerpt

Environmental carcinogenesis is traditionally explained by the accumulation of genetic alterations induced by exogenous carcinogens. However, most exposed cells do not undergo malignant transformation because intrinsic tumor-suppressive mechanisms limit the expansion of damaged clones. Among these mechanisms, cellular senescence represents a major barrier that restricts proliferation following DNA damage,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42505344
DOI: 10.3390/cells15141234
PMCID: PMC13406434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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