Article
Four evolutionary trajectories underlie genetic intratumoral variation in childhood cancer.
Nature genetics - 1 Jul 2018
Karlsson Jenny, Valind Anders, Holmquist Mengelbier Linda, Bredin Sofia, Cornmark Louise, Jansson Caroline, Wali Amina, Staaf Johan, Viklund Björn, Øra Ingrid, Börjesson Anna, Backman Torbjörn, Braekeveldt Noémie, Sandstedt Bengt, Pal Niklas, Isaksson Anders, Lackner Barbara Gürtl, Jonson Tord, Bexell Daniel, Gisselsson David
Abstract excerpt
A major challenge to personalized oncology is that driver mutations vary among cancer cells inhabiting the same tumor. Whether this reflects principally disparate patterns of Darwinian evolution in different tumor regions has remained unexplored1-5. We mapped the prevalence of genetically distinct clones over 250 regions in 54 childhood cancers. This showed that primary tumors can simultaneously follow up to four...
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