Article
Single-cell DNA sequencing identifies risk-associated clonal complexity and evolutionary trajectories in childhood medulloblastoma development.
Acta neuropathologica - 1 Sept 2022
Danilenko Marina, Zaka Masood, Keeling Claire, Crosier Stephen, Lyman Stephanie, Finetti Martina, Williamson Daniel, Hussain Rafiqul, Coxhead Jonathan, Zhou Peixun, Hill Rebecca M, Hicks Debbie, Rand Vikki, Joshi Abhijit, Schwalbe Edward C, Bailey Simon, Clifford Steven C
Abstract excerpt
We reconstructed the natural history and temporal evolution of the most common childhood brain malignancy, medulloblastoma, by single-cell whole-genome sequencing (sc-WGS) of tumours representing its major molecular sub-classes and clinical risk groups. Favourable-risk disease sub-types assessed (MBWNT and infant desmoplastic/nodular MBSHH) typically comprised a single clone with no evidence of further evolution....
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