Article
Locus-specific DNA methylation of Mecp2 promoter leads to autism-like phenotypes in mice.
Cell death & disease - 3 Feb 2020
Lu Zongyang, Liu Zhen, Mao Wei, Wang Xinying, Zheng Xiaoguo, Chen Shanshan, Cao Beibei, Huang Shisheng, Zhang Xuliang, Zhou Tao, Zhang Yu, Huang Xingxu, Sun Qiang, Li Jia-Da
Abstract excerpt
Autism spectrum disorder (ASD) is a neurodevelopmental disease with a strong heritability, but recent evidence suggests that epigenetic dysregulation may also contribute to the pathogenesis of ASD. Especially, increased methylation at the MECP2 promoter and decreased MECP2 expression were observed in the brains of ASD patients. However, the causative relationship of MECP2 promoter methylation and ASD has not been...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.