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Common DNA methylation alterations in multiple brain regions in autism.

Molecular psychiatry - 1 Aug 2014

Ladd-Acosta C, Hansen K D, Briem E, Fallin M D, Kaufmann W E, Feinberg A P

Abstract excerpt

Autism spectrum disorders (ASD) are increasingly common neurodevelopmental disorders defined clinically by a triad of features including impairment in social interaction, impairment in communication in social situations and restricted and repetitive patterns of behavior and interests, with considerable phenotypic heterogeneity among individuals. Although heritability estimates for ASD are high, conventional...

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Autistic Disorder
Case-Control Studies
Cerebellum
DNA Methylation
Epigenesis, Genetic

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Prefrontal Cortex

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PMID: 23999529
DOI: 10.1038/mp.2013.114
PMCID: PMC4184909

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