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Engineering of AAV-Mediated in Vivo Targeted DNA Methylation Editing System via Staphylococcus Aureus Derived Cas9-SunTag

2021-11-16

Abstract excerpt

DNA methylation aberrations have been implicated in the pathogenesis of various psychiatric and developmental disease states. However, basic research and therapeutic in vivo applications targeting aberrant DNA methylation are still limited due to the lack of targeted DNA methylation editing systems that work on capacity-limited adeno-associated virus (AAV), a highly versatile in vivo gene delivery vector. Here, we...

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Literature Corpus work
ef0fddb7-7a80-5ea2-a997-9e69ac689edf
DOI
10.21203/rs.3.rs-1065603/v1
Open publication

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Engineering of AAV-Mediated in Vivo Targeted DNA Methylation Editing System via Staphylococcus Aureus Derived Cas9-SunTagDOI 10.21203/rs.3.rs-1065603/v1
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