Article

Human MeCP2 binds to promoters and inhibits transcription in an unmethylated S. cerevisiae genome

2024-08-13

Abstract excerpt

MeCP2 is a DNA-binding transcriptional regulator that is present at near-histone levels in mammalian cortical neurons. Originally identified as a DNA methylation reader, MeCP2 has been proposed to repress transcription by recruiting corepressors to methylated DNA. While some genome-wide occupancy studies support a preference for methylated DNA, others suggest that MeCP2 binding is more influenced by DNA sequence a...

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Literature Corpus work: a59a8b6f-8ef8-5c7c-b79f-b500383bbf02
DOI: 10.1101/2024.08.12.607623

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