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Article

Learning-dependent chromatin remodeling highlights noncoding regulatory regions linked to autism.

Science signaling - 16 Jan 2018

Koberstein John N, Poplawski Shane G, Wimmer Mathieu E, Porcari Giulia, Kao Charlly, Gomes Bruce, Risso Davide, Hakonarson Hakon, Zhang Nancy R, Schultz Robert T, Abel Ted, Peixoto Lucia

Abstract excerpt

Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder that is associated with genetic risk factors. Most human disease-associated single-nucleotide polymorphisms (SNPs) are not located in genes but rather are in regulatory regions that control gene expression. The function of regulatory regions is determined through epigenetic mechanisms. Parallels between the cellular basis of development and...

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Identifiers

PMID: 29339533
DOI: 10.1126/scisignal.aan6500
PMCID: PMC6180319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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