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Article

Disruption of AT-hook 1 domain in MeCP2 protein caused behavioral abnormality in mice.

Biochimica et biophysica acta. Molecular basis of disease - 1 Feb 2018

Xu Miaojing, Song Pingping, Huang Wei, He Rongni, He Yong, Zhou Xiao, Gu Yong, Pan Suyue, Hu Yafang

Abstract excerpt

MECP2 is the causative gene for autism spectrum disorders, including Rett syndrome, a regressive neurodevelopmental rare disease mainly occurring in girls. Except for the distinct methyl-CpG binding domain and the transcriptional repression domain in MeCP2, three AT-hook-like domains have recently been identified. Several mutations in AT-hook 1 domain have been reported in autism cases or Rett database. However,...

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Source

Identifiers

PMID: 29074463
DOI: 10.1016/j.bbadis.2017.10.022

Genes

MECP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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