Article
Base-Editing-Mediated Artificial Evolution of OsALS1 In Planta to Develop Novel Herbicide-Tolerant Rice Germplasms.
Molecular plant - 6 Apr 2020
Kuang Yongjie, Li Shaofang, Ren Bin, Yan Fang, Spetz Carl, Li Xiangju, Zhou Xueping, Zhou Huanbin
Abstract excerpt
Recently developed CRISPR-mediated base editors, which enable the generation of numerous nucleotide changes in target genomic regions, have been widely adopted for gene correction and generation of crop germplasms containing important gain-of-function genetic variations. However, to engineer target genes with unknown functional SNPs remains challenging. To address this issue, we present here a...
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