High-efficiency and multiplex adenine base editing in plants using new TadA variants.

doi:10.1016/j.molp.2021.02.007

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Article

High-efficiency and multiplex adenine base editing in plants using new TadA variants.

Molecular plant - 3 May 2021

Yan Daqi, Ren Bin, Liu Lang, Yan Fang, Li Shaofang, Wang Guirong, Sun Wenxian, Zhou Xueping, Zhou Huanbin

Abstract excerpt

Recently reported adenine base editors (ABEs) exhibit powerful potential for targeted gene correction as well as developing gain-of-function mutants and novel germplasms for both gene function studies and crop breeding. However, editing efficiency varies significantly among different target sites. Here, we investigated the activities of three evolved E. coli adenosine deaminase TadA variants (TadA8e, TadA8.17,...

Topics

Adenine
Adenosine Deaminase
CRISPR-Associated Proteins
Escherichia coli Proteins
Gene Editing
Genome, Plant
Mutation
Oryza
Plants, Genetically Modified

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PMID: 33631420
DOI: 10.1016/j.molp.2021.02.007

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