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Article

An unbiased method for evaluating the genome-wide specificity of base editors in rice.

Nature protocols - 1 Jan 2021

Jin Shuai, Gao Qiang, Gao Caixia

Abstract excerpt

Base editors can achieve targeted genomic base conversion. However, the off-target issue is one of the major concerns in their application. Whole-genome sequencing (WGS) at the individual level can provide direct information on genome-wide specificity, but it is difficult to distinguish true off-target single-nucleotide variants (SNVs) induced by base editors from background variation. Here we describe an...

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Share to Agrobacterium tumefaciens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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PMID: 33349703
DOI: 10.1038/s41596-020-00423-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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