Article
Generating broad-spectrum tolerance to ALS-inhibiting herbicides in rice by base editing.
Science China. Life sciences - 1 Oct 2021
Zhang Rui, Chen Sha, Meng Xiangbing, Chai Zhuangzhuang, Wang Delin, Yuan Yuge, Chen Kunling, Jiang Linjian, Li Jiayang, Gao Caixia
Abstract excerpt
Herbicide-tolerant rice varieties generated by genome editing are highly desirable for weed control. We have used a cytosine base editor to create a series of missense mutations in the P171 and/or G628 codons of the acetolactate synthase (ALS) gene to confer herbicide tolerance in rice. The four different missense mutations in the P171 codon, P171S, P171A, P171Y and P171F, exhibited different patterns of...
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