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Article

Creating large-scale genetic diversity in Arabidopsis via base editing-mediated deep artificial evolution.

Genome biology - 9 Aug 2024

Wang Xiang, Pan Wenbo, Sun Chao, Yang Hong, Cheng Zhentao, Yan Fei, Ma Guojing, Shang Yun, Zhang Rui, Gao Caixia, Liu Lijing, Zhang Huawei

Abstract excerpt

BACKGROUND: Base editing is a powerful tool for artificial evolution to create allelic diversity and improve agronomic traits. However, the great evolutionary potential for every sgRNA target has been overlooked. And there is currently no high-throughput method for generating and characterizing as many changes in a single target as possible based on large mutant pools to permit rapid gene directed evolution in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39123212
DOI: 10.1186/s13059-024-03358-9
PMCID: PMC11312839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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