Article
Artificial evolution of OsEPSPS through an improved dual cytosine and adenine base editor generated a novel allele conferring rice glyphosate tolerance.
Journal of integrative plant biology - 1 Sept 2023
Zhang Chen, Zhong Xue, Li Shaoya, Yan Lei, Li Jingying, He Yubing, Lin Yong, Zhang Yangjun, Xia Lanqin
Abstract excerpt
Exploiting novel endogenous glyphosate-tolerant alleles is highly desirable and has promising potential for weed control in rice breeding. Here, through fusions of different effective cytosine and adenine deaminases with nCas9-NG, we engineered an effective surrogate two-component composite base editing system, STCBE-2, with improved C-to-T and A-to-G base editing efficiency and expanded the editing window....
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