Article
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.
Cancer cell - 1 May 2006
Lee Jeongwu, Kotliarova Svetlana, Kotliarov Yuri, Li Aiguo, Su Qin, Donin Nicholas M, Pastorino Sandra, Purow Benjamin W, Christopher Neil, Zhang Wei, Park John K, Fine Howard A
Abstract excerpt
The concept of tumor stem cells (TSCs) provides a new paradigm for understanding tumor biology, although it remains unclear whether TSCs will prove to be a more robust model than traditional cancer cell lines. We demonstrate marked phenotypic and genotypic differences between primary human tumor-derived TSCs and their matched glioma cell lines. Unlike the matched, traditionally grown tumor cell lines, TSCs...
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