Article
Prioritizing rs7294 as a mirSNP contributing to warfarin dosing variability.
Pharmacogenomics - 1 Mar 2020
Koshy Linda, Harikrishnan S, Sudhakaran P R
Abstract excerpt
Aim: The role of mirSNPs in the 3'UTR of VKORC1, CYP2C9 and CYP4F2 genes that could influence warfarin dose variability via a discrete miRNA-mediated mechanism remains unexplained. Methods: Genotypic data in the 1000 Genomes dataset were analyzed for pair-wise linkage disequilibrium and allelic enrichment. Results: MirSNP rs7294 in the 3'UTR of VKORC1 gene displayed varying strengths of linkage disequilibrium...
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