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Article

A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.

PLoS genetics - 1 Mar 2009

Takeuchi Fumihiko, McGinnis Ralph, Bourgeois Stephane, Barnes Chris, Eriksson Niclas, Soranzo Nicole, Whittaker Pamela, Ranganath Venkatesh, Kumanduri Vasudev, McLaren William, Holm Lennart, Lindh Jonatan, Rane Anders, Wadelius Mia, Deloukas Panos

Abstract excerpt

We report the first genome-wide association study (GWAS) whose sample size (1,053 Swedish subjects) is sufficiently powered to detect genome-wide significance (p<1.5 x 10(-7)) for polymorphisms that modestly alter therapeutic warfarin dose. The anticoagulant drug warfarin is widely prescribed for reducing the risk of stroke, thrombosis, pulmonary embolism, and coronary malfunction. However, Caucasians vary widely...

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Source

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Identifiers

PMID: 19300499
DOI: 10.1371/journal.pgen.1000433
PMCID: PMC2652833

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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