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Article

Novel regulatory variant detected on the VKORC1 haplotype that is associated with warfarin dose.

Pharmacogenomics - 1 Aug 2016

Cavalli Marco, Pan Gang, Nord Helena, Eriksson Niclas, Wadelius Claes, Wadelius Mia

Abstract excerpt

AIM: Warfarin dose requirement is associated with VKORC1 rs9923231, and we studied whether it is a functional variant. MATERIALS & METHODS: We selected variants in linkage disequilibrium with rs9923231 that bind transcription factors in an allele-specific way. Representative haplotypes were cloned or constructed, nuclear protein binding and transcriptional activity were evaluated. RESULTS: rs56314408C>T and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Anticoagulants

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Share to Dose-Response Relationship, Drug

Share to Gene Expression Regulation, Enzymologic

Share to Linkage Disequilibrium

Share to Vitamin K Epoxide Reductases

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Source

Identifiers

PMID: 26847243
DOI: 10.2217/pgs-2015-0013

Genes

VKORC1

Provenance

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