Article
Pharmacogenetic determinants of warfarin in the Indian population.
Pharmacological reports : PR - 1 Oct 2021
Naushad Shaik Mohammad, Kutala Vijay Kumar, Hussain Tajamul, Alrokayan Salman A
Abstract excerpt
BACKGROUND: Several studies optimized the warfarin dose based on CYP2C9*2, CYP2C9*3, VKORC1 -1639 G > A, CYP4F2 V433M. But, the information on the rare variants is lacking. In this study, we have explored the prevalence of common and rare pharmacogenetic determinants of warfarin and determined their damaging nature. METHODS: We have analyzed 2000 healthy adults using the Infinium global screening array (GSA) for...
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