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Article

Local ancestry-informed GWAS of warfarin dose requirement in African Americans identifies a CYP2C19 splicing QTL.

American journal of human genetics - 6 Nov 2025

Singh Anmol, Alarcon Cristina, Nutescu Edith A, O'Brien Travis J, Tuck Matthew, Gong Li, Klein Teri E, Meltzer David O, Johnson Julie A, Cavallari Larisa H, Perera Minoli A

Abstract excerpt

African Americans (AAs) are underrepresented in pharmacogenomics research, which has led to a significant gap in knowledge. Through admixture, AAs can inherit specific loci from either their African or European ancestors, known as local ancestry (LA). A previous study in AAs identified SNPs located in the CYP2C cluster that are associated with warfarin dose. However, LA was not considered in that study. Here, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41027428
DOI: 10.1016/j.ajhg.2025.09.006
PMCID: PMC12548095

Genes

CYP2C19
CYP2C9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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