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Article

A multi-factorial analysis of response to warfarin in a UK prospective cohort.

Genome medicine - 6 Jan 2016

Bourgeois Stephane, Jorgensen Andrea, Zhang Eunice J, Hanson Anita, Gillman Matthew S, Bumpstead Suzannah, Toh Cheng Hock, Williamson Paula, Daly Ann K, Kamali Farhad, Deloukas Panos, Pirmohamed Munir

Abstract excerpt

BACKGROUND: Warfarin is the most widely used oral anticoagulant worldwide, but it has a narrow therapeutic index which necessitates constant monitoring of anticoagulation response. Previous genome-wide studies have focused on identifying factors explaining variance in stable dose, but have not explored the initial patient response to warfarin, and a wider range of clinical and biochemical factors affecting both...

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Source

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Identifiers

PMID: 26739746
DOI: 10.1186/s13073-015-0255-y
PMCID: PMC4702374

Genes

VKORC1

Provenance

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