Article
Targeted next-generation sequencing of genes involved in Warfarin Pharmacodynamics and pharmacokinetics pathways using the Saudi Warfarin Pharmacogenetic study (SWAP).
The pharmacogenomics journal - 1 Jul 2023
Ammari Maha Al, Almuzzaini Bader, Al Sulaiman Khalid, AlBalwi Mohammed, Sultana Khizra, Alabdulkareem Ibrahim B, Almakhlafi Nada S, Humoud Anoud Al, Waheeby Mohammed, Balla Munee, Shehri Asma Al, Alharf Adel, Alghamdi Jahad
Abstract excerpt
BACKGROUND: Warfarin is an oral anticoagulant commonly used for treatment and prophylaxis against thromboembolic events. Warfarins's narrow therapeutic index window is one of the main challenges in clinical practice; thus, it requires frequent monitoring and dose adjustment to maintain patients' therapeutic range. Warfarin dose variation and response are attributed to several inter-and intra-individuals factors,...
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