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Article

Could MicroRNA polymorphisms influence warfarin dosing? A pharmacogenetics study on mir133 genes.

Thrombosis research - 1 Aug 2015

Ciccacci Cinzia, Rufini Sara, Politi Cristina, Novelli Giuseppe, Forte Vittorio, Borgiani Paola

Abstract excerpt

MicroRNAs are small single stranded molecules that play a crucial role in regulation of physiological and pathological processes. Recent studies showed that VKORC1 gene contains an highly evolutionary conserved binding site for mir-133. Moreover, in human hepatocytes mir-133 is constitutively co-expressed with VKORC1. Since VKORC1 protein is the target of warfarin treatment, the aim of this study was to verify if...

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Source

Identifiers

PMID: 26113018
DOI: 10.1016/j.thromres.2015.06.026

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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