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Article

A genetic development route analysis on MDS subset carrying initial epigenetic gene mutations.

Scientific reports - 21 Jan 2020

Li Xiao, Xu Feng, Wu Ling-Yun, Zhao You-Shan, Guo Juan, He Qi, Zhang Zheng, Chang Chun-Kang, Wu Dong

Abstract excerpt

MDS development is a dynamic process during which the accumulation of somatic mutations leads to specific malignant evolution. To elucidate the differential roles of gene mutations in typical MDS, we used targeted sequencing to investigate clonal patterns from 563 patients and focused on cases (199/563 cases) with initial mutations (ASXL1, DNMT3A and TET2) at MDS diagnosis. The consistency of frequency and...

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Identifiers

PMID: 31964915
DOI: 10.1038/s41598-019-55540-w
PMCID: PMC6972820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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