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Article

Genetics of progression from MDS to secondary leukemia.

Blood - 2 Jul 2020

Menssen Andrew J, Walter Matthew J

Abstract excerpt

Our understanding of the genetics of acute myeloid leukemia (AML) development from myelodysplastic syndrome (MDS) has advanced significantly as a result of next-generation sequencing technology. Although differences in cell biology and maturation exist between MDS and AML secondary to MDS, these 2 diseases are genetically related. MDS and secondary AML cells harbor mutations in many of the same genes and...

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Identifiers

PMID: 32430504
DOI: 10.1182/blood.2019000942
PMCID: PMC7332895

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