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Next generation sequencing reveals the mutation landscape of Chinese MDS patients and the association between mutations and AML transformations.

Hematology (Amsterdam, Netherlands) - 1 Dec 2024

Liu Yu, Cheng Huanchen, Cheng Mei, Sun Meng, Ma Jun, Gong Tiejun

Abstract excerpt

BACKGROUND/OBJECTIVE: Approximately 30% of patients with MDS eventually develop to acute myeloid leukemia (AML). Our study aimed to investigate the mutation landscape of Chinese MDS patients and identify the mutated genes which are closely implicated in the transformation of MDS to AML. METHODS: In total, 412 sequencing data collected from 313 patients were used for analysis. Mutation frequencies between...

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PMID: 39158486
DOI: 10.1080/16078454.2024.2392469

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