Article
[An update on epigenetic regulator gene mutations and pathogenesis of myelodysplastic syndromes].
Zhongguo shi yan xue ye xue za zhi - 1 Oct 2011
Wang Jie-Yu, Xiao Zhi-Jian
Abstract excerpt
The myelodysplastic syndrome (MDS) is a group of heterogeneous clonal disorders. So far, the etiology and pathogenesis of MDS is poorly understood. Recently, more and more epigenetic regulator gene such as TET2, ASXL1, EZH2, DNMT3A and UTX mutations were detected in patients with MDS: TET2 may convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). TET2 is the most frequently mutated gene in MDS known so...
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