Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression.

doi:10.1158/2643-3230.BCD-21-0155

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Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression.

Blood cancer discovery - 6 Jul 2022

Menssen Andrew J, Khanna Ajay, Miller Christopher A, Nonavinkere Srivatsan Sridhar, Chang Gue Su, Shao Jin, Robinson Joshua, O'Laughlin Michele, Fronick Catrina C, Fulton Robert S, Brendel Kimberly, Heath Sharon E, Saba Raya, Welch John S, Spencer David H, Payton Jacqueline E, Westervelt Peter, DiPersio John F, Link Daniel C, Schuelke Matthew J, Jacoby Meagan A, Duncavage Eric J, Ley Timothy J, Walter Matthew J

Abstract excerpt

Progression from myelodysplastic syndromes (MDS) to secondary acute myeloid leukemia (AML) is associated with the acquisition and expansion of subclones. Our understanding of subclone evolution during progression, including the frequency and preferred order of gene mutation acquisition, remains incomplete. Sequencing of 43 paired MDS and secondary AML samples identified at least one signaling gene mutation in 44%...

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Identifiers

PMID: 35709710
DOI: 10.1158/2643-3230.BCD-21-0155
PMCID: PMC9338759

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