Article
Clinical implications of U2AF1 mutation in patients with myelodysplastic syndrome and its stability during disease progression.
American journal of hematology - 1 Nov 2013
Wu Shang-Ju, Tang Jih-Luh, Lin Chien-Ting, Kuo Yuan-Yeh, Li Li-Yu, Tseng Mei-Hsuan, Huang Chi-Fei, Lai Yen-Jun, Lee Fen-Yu, Liu Ming-Chih, Liu Chia-Wen, Hou Hsin-An, Chen Chien-Yuan, Chou Wen-Chien, Yao Ming, Huang Shang-Yi, Ko Bor-Sheng, Tsay Woei, Tien Hwei-Fang
Abstract excerpt
We aimed to analyze clinical impacts of the U2AF1 mutation on patients with myelodysplastic syndrome (MDS) and its stability during disease progression. We checked mutation status of the U2AF1 by direct sequencing in 478 de novo MDS patients and correlated with the clinical characteristics and outcomes. We also sequentially analyzed the U2AF1 mutation in 421 samples from 142 patients to determine its stability...
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