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Analysis of core mutation and TET2/ASXL1 mutations DNA methylation profile in myelodysplastic syndrome.

Hematology (Amsterdam, Netherlands) - 1 Dec 2023

Feng Yue, Liang Haiping, Han Meining, Luo Xingchun, Zhu Yu, Liu Bei

Abstract excerpt

OBJECTIVES: The study aims to analyze genetic mutation and clinical characteristics and study their correlation with survival prognosis of patients with myelodysplastic syndromes (MDS). Moreover, the differential DNA methylation profiles between TET2 mutated (Mut)/ASXL1 wild-type (WT) and TET2-Mut/ASXL1-Mut MDS samples were investigated to explore the mechanism of MDS patients with TET2/ASXL1 mutations. METHODS:...

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PMID: 37288803
DOI: 10.1080/16078454.2023.2220222

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