Article

Phase Behavior of TDP-43 and hnRNPH1: From Soluble and Aggregated States to Liquid-Like Droplets

2025-11-12

Abstract excerpt

Cytotoxic inclusions of TAR DNA-binding protein 43 (TDP-43) have been identified in various neurodegenerative diseases. Mediated by its low-complexity C-terminal domain (CTD), TDP-43 can undergo liquid-liquid phase separation (LLPS) and form aggregates and fibrils. These phase transitions are associated with pathological TDP-43 mislocalization and cytoplasmic aggregation. What determines whether and when TDP-43 ad...

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Literature Corpus work: 96a957a3-8480-5875-b93e-845440bb80e9
DOI: 10.1101/2025.11.12.687994

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