Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.

International journal of biological macromolecules - 1 Dec 2022

Chen Chen, Fu Gaohong, Guo Quanqiang, Xue Song, Luo Shi-Zhong

Abstract excerpt

Liquid-liquid phase separation (LLPS) drives the formation of extensive membrane-less compartments to regulate various cellular biological activities both physiologically and pathologically. It has been widely accepted that LLPS is closely related to amyloid diseases and increasing reports have linked this phenomenon to cancers. Mutations of tumor suppressor protein p53 exist in more than half of malignant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical Phenomena
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Static Electricity

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 36108750
DOI: 10.1016/j.ijbiomac.2022.09.087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.PMID 36108750Read ↗

Liquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains.Semantic proximity Read ↗

The chameleonic behavior of p53 in health and disease: the transition from a client to an aberrant condensate scaffold in cancerSemantic proximity Read ↗

Nucleo-cytoplasmic environment modulates spatiotemporal p53 phase separation.Semantic proximity Read ↗

Aberrant phase separation and cancer.Semantic proximity Read ↗

Phase Separation and Prion‐Like Aggregation of p53 Family Tumor Suppressors: From Protein Evolution to Cancer TreatmentSemantic proximity Read ↗

CP-31398 restored the functional condensates of R175H p53 by stabilizing the zinc-binding domain and 251-258 segment.Semantic proximity Read ↗

The molecular mechanism of temperature-dependent p53C phase separation accelerated by oncogenic mutations: insights from all-atom and coarse-grained molecular dynamics simulations.Semantic proximity Read ↗

Is there a role of phase partitioning in coordinating DNA damage response?Semantic proximity Read ↗

Protein phase separation and its role in tumorigenesis.Semantic proximity Read ↗

Liquid‒liquid phase separation: roles and implications in future cancer treatment.Semantic proximity Read ↗

TAR DNA-binding protein 43 (TDP-43) liquid-liquid phase separation is mediated by just a few aromatic residues.Semantic proximity Read ↗

Phase-Separated Biomolecular Condensation in Cancer: New Horizons and Next Frontiers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.