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Article

CP-31398 restored the functional condensates of R175H p53 by stabilizing the zinc-binding domain and 251-258 segment.

Colloids and surfaces. B, Biointerfaces - 1 Jun 2026

Liu Yang, Liu Yuan, Xu Chang, Jiang Fangming, Yang Xiaorong

Abstract excerpt

Tumor suppressor p53 formed the droplets with the solidification tendency. Mutations in p53 could accelerate the aggregation of droplets, resulting in p53 to lose the function and/or to gain the oncogenic activity. In this study, the effects of CP-31398 on the phase behaviors of p53 mutants were explored. The results revealed that CP-31398 could inhibit the pathological aggregation of R175H p53, restored the...

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PMID: 41610648
DOI: 10.1016/j.colsurfb.2026.115474

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CP

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