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Article

Molecular principles of recruitment and dynamics of guest proteins in liquid droplets.

Scientific reports - 29 Sept 2021

Kamagata Kiyoto, Iwaki Nanako, Hazra Milan Kumar, Kanbayashi Saori, Banerjee Trishit, Chiba Rika, Sakomoto Seiji, Gaudon Virginie, Castaing Bertrand, Takahashi Hiroto, Kimura Michiko, Oikawa Hiroyuki, Takahashi Satoshi, Levy Yaakov

Abstract excerpt

Despite the continuous discovery of host and guest proteins in membraneless organelles, complex host-guest interactions hinder the understanding of the molecular grammar governing liquid-liquid phase separation. In this study, we characterized the localization and dynamic properties of guest proteins in liquid droplets using single-molecule fluorescence microscopy. Eighteen guest proteins of different sizes,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34588591
DOI: 10.1038/s41598-021-98955-0
PMCID: PMC8481498

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