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Article

Functional Tolerance to Cysteine Mutations in Human α7 Nicotinic Acetylcholine Receptors.

ACS chemical neuroscience - 5 Feb 2020

Tillman Tommy S, Choi Zachary, Xu Yan, Tang Pei

Abstract excerpt

The α7 nicotinic acetylcholine receptor (α7 nAChR) is involved in various intracellular signaling pathways that mediate addiction, chronic pain, and other diseases, but its intracellular domain structures remain undetermined. The presence of 17 native cysteines in α7 nAChR provides opportunities for extracting structural information through site-directed labeling of chemical probes in strategic locations, but it...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31951367
DOI: 10.1021/acschemneuro.9b00647
PMCID: PMC7057392

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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