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Article

Single amino acid substitutions modulate the function of α9α10 nicotinic acetylcholine receptor.

International journal of biological macromolecules - 1 May 2026

Zhou Xuan, Jiang Xiu, Pei Shengrong, Yu Jinpeng, McIntosh J Michael, Zhangsun Dongting, Zhu Xiaopeng, Luo Sulan

Abstract excerpt

The α9α10 nicotinic acetylcholine receptor (nAChRs) is a potential therapeutic target for several diseases, including inner ear disorders, chronic pain, cancer, pemphigus vulgaris, and inflammatory disorders. However, the influence of key sites that modulate the receptor's pharmacological properties remains unclear. The crystal and cryo-electron microscopy structures of various nAChRs have helped elucidate...

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Identifiers

PMID: 41966377
DOI: 10.1016/j.ijbiomac.2026.151936

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