Article
Basic Residues at Position 11 of α-Conotoxin LvIA Influence Subtype Selectivity between α3β2 and α3β4 Nicotinic Receptors via an Electrostatic Mechanism.
ACS chemical neuroscience - 20 Dec 2023
Haufe Yves, Kuruva Veeresh, Samanani Ziyana, Lokaj Gonxhe, Kamnesky Guy, Shadamarshan PranavKumar, Shahoei Rezvan, Katz Dana, Sampson Jared M, Pusch Michael, Brik Ashraf, Nicke Annette, Leffler Abba E
Abstract excerpt
Understanding the determinants of α-conotoxin (α-CTX) selectivity for different nicotinic acetylcholine receptor (nAChR) subtypes is a prerequisite for the design of tool compounds to study nAChRs. However, selectivity optimization of these small, disulfide-rich peptides is difficult not only because of an absence of α-CTX/nAChR co-structures but also because it is challenging to predict how a mutation to an...
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